内容提要
美国警告阿片类与苯二氮卓类等药物联合使用导致的严重风险
加拿大进一步限制可待因在儿童和青少年中的使用
加拿大评估氢可酮导致儿童与青少年呼吸抑制风险
加拿大警告抗抑郁药引起的闭角型青光眼风险
ribenfabuguoyangbenjiaxiandengyaopinshuomingshugengxinxinxi
美国警告阿片类与苯二氮卓类等药物联合使用导致的严重风险
2016nian8yue31ri,meiguoshipinyaopinliju（fda）pinggufaxian，apianleiyaowuyubenerdanzhuoleihuoqitayizhizhongshushenjingxitong（cns）deyaowulianheshiyongdexianxiangriyizengduo，zheizhonglianheyongyaohuidaozhiyanzhongdefuzuoyong，baokuohuxijianmanhuohuxikunnan，shenzhisiwang。weijianshaoapianleiyubenerdanzhuoleihuoapianleiyuqitacnsyizhijilianheshiyongdeqingkuang，fdatichuyanzhongjinggao，yaoqiuzaiapianleizhentongyaohezhikeyaoyijibenerdanzhuoleiyaowudeshuomingshuzhongtianjiaheikuangjinggao。
apianleiyaowushiqiangxiaomazuiyao，yongyuzhiliaowufashiyongqitazhentongyaohuoqitazhentongyaobunengchongfenhuanjietengtongdehuanzhe。apianleideyanzhongfengxianbaokuowuyong、lanyong、chengyin、guolianghesiwang。apianlei（rukedaiyinheqingketong）haibeipizhunyuqitayaowulianhezhiliaokesou。benerdanzhuoleiyaowuweiyileiguangfanshiyongdeyaowu，keyizhiliaobaokuojiaolv、shimianhedianxianfazuozaineidejibingzhengzhuang。apianleihebenerdanzhuoleiyaowudouhuiyizhicns。
fdashenchadeduoxiangyanjiujieguoxianshi，lianheshiyongapianleihebenerdanzhuolei、qitayizhicnsyaowuhuojiujingkechuxianyanzhongfengxian。
合并使用苯二氮卓类与阿片类药物
fdakaizhandeliangxiangyanjiuxianshi，hebingshiyongapianleizhentongyaohebenerdanzhuoleiyaowuchengshangshengqushi，hebingshiyongbenerdanzhuoleiheapianleidewuyong、lanyongheguoliangdepincizengjia，zheishigenjuguojiajizhenke（national emergency department，ed）jiuzhenshujuheguoliangsiwanglvcesuansuodedejieguo。
diyixiangyanjiupingguhebingshiyongapianleizhentongyaohebenerdanzhuoleideshiyongmoshi。2002nianzhi2014nianjian，meinianpeifaapianleiyaowudehuanzheshuliangzengjia8%，cong7500wanzengjiazhi8100wan，meinianpeifabenerdanzhuoleiyaowudehuanzheshuliangzengjia31%，cong2300wanzengjiazhi3000wan。zaiciqijian，apianleizhentongyaozhiliaohuanzhetongshijieshoubenerdanzhuoleichufangyaodebilizengjia41%，yejiushishuo，he2002nianxiangbi，2014nianapianleizhentongyaohebingbenerdanzhuoleidehuanzheshuliangzengjia250wanyishang。jieshouhebingchufangyaogailvzuigaodeyazushinvxinghe65suiyishangzhangqishiyongapianleizhentongyaodehuanzhe。raner，ruguocaiyongjueduishuzi，zeapianleizhentongyaodefeizhangqishiyongzhehebingyongyaodeshuliangzuiduo，yinweizheigehuanzhequndeshuliangyuanyuandayuzhangqishiyongzhe。
dierxiangyanjiushiyongyaowulanyongjingshiwang（drug abuse warning network，dawn）fenxifeiyiliaomudeshiyongapianleizhentongyaohebenerdanzhuoleihouedjiuzhenshuju，shiyongguojiazhongyaotongjixitongduoyinsiwangwenjian（national vital statistics system multiple cause-of-death file）fenxiyuchufangapianleizhentongyaohebenerdanzhuoleiyaowuyouguandeyaowuguoliangsiwangshuju。cong2004nianzhi2011nian，feiyiliaomushiyonghouedjiuzhendefashenglv（baokuoapianleizhentongyaohebenerdanzhuolei），congmei10wanhuanzhe11lizengjiazhi34.2li（p<0.0001）。tongyishiqinei，apianleizhentongyaohebenerdanzhuoleiyaowuguoliangsiwanglv（baokuochufangjilianghedayuchufangjiliang）congmei10wanren0.6lizengjiazhi1.7li（p<0.0001）。zaizheiduanshijiannei，shiyongbenerdanzhuoleiyaowudehuanzhe，fashengapianleizhentongyaoguoliangsiwangdebili，cong18%zengjiazhi31%（p<0.0001）。
yixuewenxianzhonglingwailiangxiangyanjiuxianshichushiyongapianleizhentongyaohebenerdanzhuoleiyaowudehuanzhefashengbuliangshijiandefengxianshangshengdegengzhijiezhengju。zaibeikaluolainazhoukaizhandeqianzhanxingguanchaxingduilieyanjiufaxian，lianheshiyongapianleizhentongyaohebenerdanzhuoleiyaowudehuanzhezhong，guoliangsiwanglv（7.0/10,000huanzhenian；95%ci：6.3-7.8）bidandushiyongapianleizhentongyaodehuanzhe（0.7/10,000huanzhenian；95% ci：0.6-0.9）gaochu10beiyishang。haiyouyixiangduilieyanjiupinggule2004-2009niandetuiwujunrenjiankangguanlishuju，faxianhebingshiyongapianleizhentongyaohebenerdanzhuoleiyaowudehuanzhe，yaowuguoliangsiwangdefengxianzengjia。yumeiyoubenerdanzhuoleiyongyaoshidehuanzhexiangbi，juyoubenerdanzhuoleiyongyaoshidehuanzheshiyongapianleizhentongyaoguoliangzhisidefengxianshenggao（hr= 2.33，95%ci: 2.05 2.64），neixiemuqianshiyongbenerdanzhuoleichufangyaodehuanzhefashengguoliangzhisidefengxianzengjialeisi（hr=3.86，95%ci: 3.49 4.26）。ciwai，suizhebenerdanzhuoleiyaowumeirijiliangzengjia，yaowuguoliangsiwangdefengxianzengjia。
genjuzheisixiangyanjiumiaoshudehebingshiyongapianleizhentongyaohebenerdanzhuoleiyaowuxianxiangzengjiayijihebingshiyonghouweihaizengjiadequshi，fdayaoqiuzaiapianleizhentongyaoheapianleizhikeyaoyijibenerdanzhuoleiyaowudeshuomingshuzhongtianjiaxindeheikuangjinggaoxinxi。shuomingshudejinggaohezhuyishixiang、yaowuxianghuzuoyonghehuanzheyongyaojianyixinxibufenyeyaozuochuxiangyingxiuding。
合并使用阿片类药物和其他CNS抑制剂
jinqiwenxianfabiaodeyanjiuxianshi，hebingshiyongapianleizhentongyaoyucnsyizhiji（chubenerdanzhuoleiwai，baokuojiujing）yeyuyanzhongbuliangshijianxiangguan。yixiangyanjiubaogaocheng，zaipandingbenerdanzhuoleiyaowushisiwangyuanyindebaogaozhong，hebingshiyongapianleizhentongyaodezhan77%，zaipandingapianleizhentongyaoshisiwangyuanyindebaogaozhong，hebingshiyongbenerdanzhuoleiyaowudezhan30%。zheixiangyanjiuhaifenxilezheixiesiwangbinglizhongqitacnsyizhiji（baokuobabituolei、kangjingshenbingyao、zhenjingcuimianyao、kangdianxianyao、kangpajinsenbingyao、mazuiyao、zizhushenjingxitongyaowuhejirousongchiji）deyingxiang，faxianbufenshiyongapianleizhentongyaodebingli，zheixiecnsyizhijiyeshisiwangdecufayinsu。dierxiangyanjiufenxile2010niandawnshuju，faxian18.5%deapianleizhentongyaolanyongxiangguanedjiuzhenyujiujingyouguan，22.1%deapianleizhentongyaoxiangguansiwangyujiujingyouguan。
suoyouyanjiudoushijiyuapianleizhentongyaokaizhande，raneryouyuyaolitexingleisi，yinciyuqihebingshiyongapianleizhikeyaohebenerdanzhuolei、qitacnsyizhijihuojiujingdefengxianyuapianleijiejinshihelide。genjuzheixieyanjiu，apianleizhentongyaohezhikeyaodeheikuangjinggaoyehuiqiangdiaoyuqitacnsyizhijihebingshiyongdefengxian。
kaolvdaoshiyongyaowufuzhuliaofa（mat）zhiliaoapianleichengyinheyilaideduteyiliaoxuqiuhehuoyi/fengxian，fdajiangjixupingguhebingshiyongbenerdanzhuoleihematyaowudekeyongzhengju。
fdatixingyiwurenyuan，yinggaixianzhiapianleizhentongyaoyubenerdanzhuoleihuoqitacnsyizhijilianheshiyong，jinyongyuqitatidailiaofaliaoxiaobuchongfendehuanzhe。ruguohebingchufangzheixieyaowu，yinggaijiangmeizhongyaowudejiliangheliaochengxianzhizainenggoudadaolixianglinchuangliaoxiaodezuidishuiping。fdajinggaohuanzhehekanhuzhezhuyihuxijianman、huxikunnanhe／huozhenjingdefengxian，yijixiangguandetizhenghezhengzhuang。bimianjizhengzaishiyongbenerdanzhuoleihuoqitacnsyizhiji（baokuojiujing）dehuanzhechufangapianleizhikeyao。
hebingshiyongapianleiyaowuyubenerdanzhuolei、qitacnsyizhijihuojiujingdehuanzhe，ruguochuxianshaojiandetouyunhuoxuanyun、jidushishui、huxijianman、huxikunnanhuowufanying，yinggailijijiuyi。wufanyingshizhihuanzhebunengzhengchanghuiyinghuozuochufanying，huozhebunenghuanxinghuanzhe。ruguoduishiyongapianleihuobenerdanzhuoleihaiyouyiwenhuodanyou，yingyuyiwurenyuangoutong。
FDA列出的阿片类、苯二氮卓类药物和其他CNS抑制剂如下：
·阿片类镇痛止咳处方药：阿芬太尼（alfentanil）、丁丙诺啡、布托啡诺、可待因、二氢可待因、芬太尼、氢可酮、氢吗啡酮、哌替啶、美沙酮、吗啡、羟考酮、羟吗啡酮（oxymorphone）、喷他佐辛、瑞芬太尼、舒芬太尼、他喷他多(tapentadol)、曲马多。
·苯二氮卓类：阿普唑仑、氯氮卓、氯巴占（clobazam）、氯硝西泮、氯拉卓酸(clorazepate )、地西泮、艾司唑仑、氟西泮、劳拉西泮、奥沙西泮、夸西泮（quazepam）、替马西泮(temazepam )、三唑仑。
·其他镇静催眠药：仲丁巴比妥钠(butabarbital sodium)、右佐匹克隆、戊巴比妥、雷美替胺(ramelteon)、司可巴比妥钠、苏沃雷生（suvorexant）、扎来普隆、唑吡坦。
·肌肉松弛剂：巴氯芬、卡立普多（carisoprodol）、氯唑沙宗、环苯扎林(cyclobenzaprine)、丹曲林钠、美他沙酮(metaxalone)、美索巴莫、奥芬那君（orphenadrine）、替扎尼定。
·kangjingshenbingyao：alipaizuo、asaineiping(asenapine)、kalilaqin（cariprazine）、lvbingqin、lvdanping、fufennaijing、fupaidingchun、yipanlitong(iloperidone)、luoshaping、lulaxitong(lurasidone)、mayintong(molindone)、aodanping、palipaitong、fennaijing、pimavanserin、kuiliuping、lipeitong、liulidaqin、tiwosaidun（thiothixene）、sanfulaqin、qilaxitong。
（美国FDA网站）
加拿大进一步限制可待因在儿童和青少年中的使用
zai2013nianhe2015nian，yinhankedaiyinyaopinyuweijishengmingdehuxiwentideqianzaifengxianxiangguan，jianadaweishengbuduihankedaiyinyaopinshishileanquanxingshencha，dangshijianyi，zainianlingwei12suiyixiadeertongzhong，buzaishiyonghankedaiyindeyaopin。jianadaweishengbujinqishishilexindeanquanxingshencha，zhizaijinyibupinggukedaiyinzaiertongjiqingshaonianhuanzhezhongcunzaideyanzhonghuxiwenti，yijuedingzaigainianlingzuzhongshifouxuyaocaiqugengduocuoshilaiguanlicifengxian。
kedaiyinjingganzangzhuanhuaweimafei，zheiliangzhongyaopinjunshuyuapianleiyaowu。yizhiapianleiyaowukeyijianhuanhuxisudu，sheruguoduoapianleiyaopinkejianhuanhuxiqiezuyiweijishengming。youxiehuanzheshichaokuaisudaixiezhe，zheiyiweizhetamenkeyigengxunsuhewanquandijiangkedaiyinzhuanhuaweimafei，zaisheruhankedaiyinyaopinhou，tamendexueyezhonggengkenenghanyoudayuyuqiliangdemafei，yincihuigengjiaweixian。zaijianada，hankedaiyinyaopinyongyuzhiliaotengtongjizhike。kedaiyinkedanyonghuoyuqitayaowulianyong，yixiehankedaiyinyaopinjinketongguochufanghuode，erqitaweifeichufangyao。duiyuhankedaiyindefeichufangyao，xiaofeizhezaigoumaiqian，bixuzixunyaojishi。hankedaiyinyaopindeanquanxingxinxitishi，ruguohuanzhehuanyoudaozhihuxikunnandejibing，ruxiaochuan、manxingfeibinghuoqitahuxiwenti，yingjinyonghankedaiyindeyaopin。
zaianquanxingshenchajinxingqijian，jianadaweishengbugongshoudao8likenengyuchufangkedaiyinzhiliaotengtongyouguanqienianlingzai18suiyixiayouhuxiwentidejianadahuanzhebingli。zheixiebinglizhongde6lifashengzainianlingwei12suiyixiadeertongzhong，qizhong3lisiwang。8libinglizhongde4lifashengzaishoushuqiechubiantaotihuolinbazuzhihoudeertongzhong。zhidezhuyideshi，yuhankedaiyinyaopintongyishijiansherudeqitayaowuyekenengdaozhihuanzhedehuxiwenti。lingwaifaxian，zaifabiaodehuanzhenianlingwei18suiyixia、shiyongkedaiyinzhiliaotengtongde7liguojibinglizhong，chufangkedaiyinkenengyuyanzhonghuxiwentixiangguanlian。7lizhongde6liwei12suiyixiaertong，qizhong4lisiwang。7libinglizhongde5lifashengzaishoushuqiechubiantaotihuolinbazuzhideertongzhong。zhidezhuyideshi，zheixieertonglihuandeqitajibingyekenengdaozhihuxiwenti。
zi2013shenchayilai，jianadaweishengbushangweishoudaorenheertonghuoqingshaonianshiyongkedaiyinfeichufangyaozhiliaotengtonghuozhikedaozhiyanzhonghuxiwentidebingli。zainianlingwei12suizhi18suidehuanzhe（baokuo2013shenchaqiandehuanzhe）deguojibinglibaogaozhong，yinxinxibuzuwufatuiduankedaiyindaozhisuobaogaodefuzuoyong。baogaozhongquefakedaiyinshiyongjiliangxiangguandexinxi，yijishifouyuzaijianadashiyongdefeichufangyaodeguigexiangsi。zi2013nianshenchayilai，kexuewenxianzhongweibaogaoshejishiyongfeichufangguigedekedaiyindexinbingli。zongtieryan，yu2013nianshenchafaxiandeqingkuangxiangbi，weifaxianxinzhengjubiaomingkedaiyinfeichufangyaodeshiyongdaozhideyanzhonghuxiwentifengxianyousuobianhua。
yixiebaogaohenhaodimiaoshuleweiman18suihuanzheshiyongkedaiyinchufangyaozhiliaobiantaotihuolinbazuzhiqiechushuhoudetengtongshidaozhideweijishengmingdehuxiwenti。yinci，jianadaweishengbuyushengchanshanghezuo，gengxinlechanpinanquanxingxinxi，shikedaiyinchufangyaozaiertongheqingshaonianzhongbuzaiyongyucixiangzhiliao。
jianadaweishengburengranjianyi，hankedaiyindeyaopinbuzai12suiyixiadeertongzhongshiyong。duiyucunzaihuxijibingdehuanzhe，wulunnianlingdaxiao，junjianyiyingjinshenshiyong。yujianadashichangzhongdesuoyoujiankangchanpinyiyang，jianadaweishengbujiangjixujiancekedaiyindefuzuoyongxinxi，quedinghepingguqiqianzaiweihai。
（jianadaweishengbuwangzhan）
加拿大评估氢可酮导致儿童与青少年呼吸抑制风险
2016nian7yue28ri，jianadaweishengbufabuxinxi，jinggaoguoliangsheruqingketongdaozhiertongheqingshaonianhuxiyizhi。hanqingketongdechanpinshuomingshuyiduicifengxiantichulejinggao，zheiyifengxiancunzaiyubaokuoertongzaineidesuoyounianlingzuzhong。jianadaweishengbuzhenduiqingketongkaizhanleanquanxingpinggu，jinyibuyanjiuertongyuqingshaonianzhongdeyanzhonghuxiyizhifengxian，cicianquanxingpingguyuanyuzhenduikedaiyin（lingyizhongapianleiyaowu）deshencha，yimingqueshifouxuyaocaiqugengduodeanquanxingcuoshi。
qingketongshiyizhongapianleichufangyaowu，yongyuhuanjiejulieganke（wutan），zi20shiji50niandaimozaijianadashangshixiaoshou。jianadajianyikejiangyixiehanqingketongchanpinyongyu6suiyixiaertong。ranerjinnianlai，qingketongzaiertongheqingshaonianzhongdechufangshuliang（shoucigouyaohezaicigouyao）cong2010niande42,000xiajiangzhi2014niande28,000。
cicijianadaweishengbugongpinggule7lishejiertongheqingshaonianshiyongqingketongqijianchuxianyanzhonghuxiwentihuoqingketongguoliangdebaogao。2libaogaofenbiesheji7suihe15suiertong，1lirenweiyuqingketongshiyongxiangguan，ling1litigongdexinxibuzu，wufaduiyinguoguanxijinxingpinggu。sheji6suiyixiaertongbaogao5li，jinyibufenxifaxian3lirenweiyuqingketongshiyongxiangguan。qizhong2libaogaolesiwangshijian，fenbiesheji1ming2suiertonghe1ming5suiertong，1lirenweiyuqingketongshiyongxiangguan，ling1libaogaotigongdexinxibuzu，wufapandingsiwangshifouyuqingketongxiangguan。
tongguoduiyifabiaowenxiansuojinxingjiansuo，faxianle1lisheji3suiertongdeguowaibingli，huanershiyongqingketonghoufashengleyanzhonghuxikunnanbingsiwang，jinyibushenchahoufaxiangaishijiankenengyuqingketongdeshiyongxiangguan。juedaduoshubinglizhong，ertongsuoshiyongdeqingketongjilianggaoyuqinianlingzutuijianjiliang。genjumuqianguanyuqingketongfuzuoyongdezhengju，shangbunengquedingqingketongyukedaiyinyiyang，shiyouyudaixiesulvwentizaochengdehuxikunnan。
jianadaweishengbujiangyushengchanshanghezuo，gengxinqingketongdechanpinxinxi，shuomingbuzaituijian6suiyixiaertongshiyongbenpin。
（jianadaweishengbuwangzhan）
加拿大警告抗抑郁药引起的闭角型青光眼风险
jianadaweishengbuwangzhan2016nian8yue12rifabuxinxicheng，zaihuoximeiguoshipinyaopinguanlijuzhengzaishenchakangyiyuyaodebijiaoxingqingguangyanfengxianhou，jianadaweishengbushishileyixianganquanxingpinggu。bencipingguzhizaiquedingjianadakangyiyuyaochanpinxinxizhongbijiaoxingqingguangyandexianyoufengxianxinxishifouzhunque，yijishifouyudangqiankexuezhengjuxiangfu。
bijiaoxingqingguangyanshiyizhongyanzhongyanbujibing，biaoxianweiyanneifangshuipaichushouzuyinqiyanneiyazhouzeng，congerdaozhitengtongjishilimohu。rubujishizhiliao，bijiaoxingqingguangyankedaozhiyongjiuxingshilisangshi。kangyiyuyaoshiguangfanshiyongdeyaowu，zi20shiji50niandaiyilaizaijianadashangshixiaoshou，yongyuzhiliaoyiyuzheng、jiaolvzheng、qiangpozheng、shimianhechuangshanghouyingjizhangaidengjibing。zi2009nianyilai，jianadadekangyiyuyaochufangyimeinian5.6％depingjunsulvzengzhang，2013nianjugujiyikaiju4050wanfenkangyiyuyaochufang。jianadaweishengbuanquanxingshenchazhezhongyuzaijianadashangshidexialie23zhongkangyiyuyao：dixipaming、bingmiqin、lvmipaming、duosaiping、qumipaming、amitilin、qujiatilin、maputilin、midanping、benyijing、malvbeian、tranylcypromine、fuxiting、xitaipulan、paluoxiting、shequlin、fufushaming、aisixitaipulan、wenlafaxin、duluoxiting、qujiawenlafaxin、quzuotong、anfeitatong。
zaishenchaqijian，congbutonglaiyuangongjiansuodao163lishiyongkangyiyuyaoxiangguandebijiaoxingqingguangyandebaogao，jianadaweishengbutongguojianadajingjiejihuashoudao2licileibaogao。zaishenchaqijian，congbutonglaiyuangongjiansuodao2226lishiyongkangyiyuyaoxiangguandetongkongkuodadebaogao，jianadaweishengbutongguojianadajingjiejihuashoudao130licileibaogao。zhongsuozhouzhi，tongkongfangdashiyixiangweixianyinsu，kedaozhimouxiehuanzhe（yanneifangshuitongdaoxiazhaihuanzhe）fashengbijiaoxingqingguangyan。
shenchafaxiankangyiyuyaodeshiyongyubijiaoxingqingguangyanyouguanlian，qiebutongkangyiyuyaoyinqibijiaoxingqingguangyandefengxianshuipingwuchayi。yinci，jianadaweishengbujianyizaisuoyoukangyiyuyaodechanpinxinxizhongliechubijiaoxingqingguangyandeqianzaifengxian。jianadaweishengbuyukangyiyuyaochanpinshengchanshanghezuo，gengxinlejianadachanpinxinxi，naruyukangyiyuyaoshiyongxiangguandebijiaoxingqingguangyandefengxianjinggao。
（jianadaweishengbuwangzhan）
日本发布过氧苯甲酰等药品说明书更新信息
ribenhoushenglaodongsheng（mhlw）heyaopinyiliaoqixieguanliju（pmda）jinqixuanbuleyouguanguoyangbenjiaxiandengyaopinshuomingshugengxinxinxi，zheixiexinxikanzaizai2016niandi4qi《who pharmaceuticals newsletter》shang。
guoyangbenjiaxianzhiji（bepioheduacfuheningjiao）deshuomingshuyigengxin，zaizhuyishixiangzhongnaruleguangfanzhongzhangfengxian。guoyangbenjiaxiandeshiyingzhengweixunchangxingcuochuang，kezuoweidanyaohuoyukelinmeisu（duacfuheningjiao）lianyong。zairiben，gongyou7libinglizaishiyongguoyangbenjiaxianhoubaogaolepifuzhengzhuang。zaizheixiebinglizhong，6libinglideyinguoguanxiwufapaichu。zaiyanjiulexianyouzhengjujitingquzhuanjiajianyihou，mhlw/pmdadechujielun：xuyaojianghongban、zhongzhangmanyanzhizhenggemianbujijingbudebinglibaogaojiangzuoweiyixiangzhuyishixiangjiarushuomingshu。
suogongsuyongyuyoudaohezengqiangzigongshousuojizhiliaozigongchuxue。zairibengongbaogaole5liyushiyongsuogongsuxiangguandeguominbingli，qizhong3libinglideyinguoguanxiwufapaichu（1lishuyushuomingshujinjideqingkuang）。zaiyanjiulexianyouzhengjujitingquzhuanjiajianyihou，mhlw/pmdaxuanbuduisuogongsushuomingshujinxingxiuding。
erlinsuanyanleiyaopin（yitilinsuan、pamilinsuan、alunlinsuan、lisailinsuan、zuolailinsuan、minuolinsuanheyibanlinsuan）deshuomingshuyigengxin，naruwaierdaoguhuaisifengxian。erlinsuanyandeshiyingzhengshiguzhishusongzheng、pagetgubing，huoyongyuzaoqihuowanqiyiweiguhuadeyufang。zaiouzhou，waierdaoguhuaisibeilieruerlinsuanyanchanpintezhenggaiyaozhong。ciwai，zairibenjiqitaguojia，erlinsuanyanzhiliaohuanzhezhongyiyoubinglibaogao。zaiyanjiulexianyouzhengjujitingquzhuanjiajianyihou，mhlw/pmdadechujielun：youbiyaoduishuomingshujinxingxiuding。
shuanglvfensuanzhiji（voltarenherectos）deshuomingshuyigengxin，zaibuliangfanyingbufennaruweichangdaoxiazhaihegengzufengxian。shuanglvfensuanshiyizhongfeizaitikangyanyao，yongyuhuanjietengtonghekangyan。zairiben，gongyou5libinglibaogaoweichangdaoxiazhaihuogengzuyushiyongshuanglvfensuanxiangguan。zaizheixiebinglizhong，4libinglideyinguoguanxiwufapaichu（1libingliweichaoshuomingshuyongfayongliang）。ciwai，gongsihexinshujubiao（ccds）yigengxin。zaiyanjiulexianyouzhengjujitingquzhuanjiajianyihou，mhlw/pmdadechujielun：youbiyaoduishuomingshujinxingxiuding。
zuoyilaxitan（e keppra）deshuomingshuyigengxin，zaibuliangfanyingbufennarujixingshenshuaijiedefengxianxinxi。zuoyilaxitanyongyuzhiliaodianxianhuanzhe（baokuojifaxingquanshenxingdianxianfazuo）dedianxianbufenxingfazuo；zuoyilaxitanhaizuoweiqitakangdianxianyaowudefuzhuyongyao，zaiqitakangdianxianyaowuhuanjiebujiadehuanzhezhong，yongyuzhiliaoqiangzhizhenluanxingdianxianfazuo。zairiben，gongbaogaole7lishiyongzuoyilaxitanxiangguandejixingshenshuaijiebingli。zaizheixiebinglizhong，2libinglideyinguoguanxiwufapaichu。jiyuribenheqitaguojiabaogaodebingli，gongsidehexinshujubiao（ccds）yijingjinxinglegengxin。zaiyanjiulexianyouzhengjujitingquzhuanjiajianyihou，mhlw/pmdadechujielun：youbiyaoduishuomingshujinxingxiuding。
